Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism, yet our knowledge of the causes and ...
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Can you lose an ay chromosome?
As males age, some of their cells may lose the Y chromosome. It was once thought that after guiding the development of male sex organs in a fetus, the Y chromosome didn't do much else. But over the past few years, results from multiple studies have challenged that belief.
What is the mosaic loss of Y chromosome?
Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY is present in the kidney and increases with age and chronic kidney disease.
Fifteen-year trajectories of multimorbidity and polypharmacy in ...
www.ncbi.nlm.nih.gov › PMC8880753
After stratifying for age, sex and multimorbidity at baseline, our aim is to analyse time trends in incident multimorbidity and polypharmacy in the 15-year ...
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Apr 26, 2022 · Machine-learning aided in situ drug sensitivity screening predicts treatment outcomes in ovarian PDX tumors · Max J. Cotler · Khalil B. Ramadi.
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We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis ...
Jan 6, 2021 · Here, modularly programmed, polyethyleneimine (PEI)‐based NP vaccines are reported for simple production of personalized cancer vaccines.
Missing: PMC6887549/ | Show results with:PMC6887549/
We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis ...
The current study substantially expands this observation, demonstrating that LOY is associated with dysregulation of autosomal gene expression in leukocytes.
Relation: http://www.ncbi.nlm.nih.gov/pmc ... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181819/ ... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887549/pdf/ ...
Mar 11, 2022 · Microenvironmental biophysical factors play a fundamental role in controlling cell behaviors including cell morphology, proliferation, ...
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Nov 20, 2019 · Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1–5, yet our knowledge of the ...