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Increased RNA and protein degradation is required for ... - bioRxiv

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Jan 27, 2023 · Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells.

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Transcriptomic, clonal, and functional analyses reveal Liver tissue ...

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Mar 29, 2024 · We hypothesize that circulating self-antigen-specific CD4 T cells contain dominant hepatic CD4 T cell clonotypes and represent liver-derived ...

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An evolutionarily conserved strategy for ribosome binding and inhibition ...

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Jun 8, 2023 · Modeling of interactions of four Nsp1s to the ribosome identified few absolutely conserved amino acids that, together with an overall ...

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Designing epitope-focused vaccines via antigen reorientation - bioRxiv

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Dec 21, 2022 · We demonstrate the generalizability of this approach to antigens from the Ebola virus, SARS-CoV-2, and influenza and observe enhanced antibody ...

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Functional gene delivery to and across brain vasculature of ...

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Jan 13, 2023 · Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing ...

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Transcriptional heterogeneity in cancer-associated regulatory T ...

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Nov 26, 2018 · We identified distinct transcriptional TI Treg cell fates, with a suppressive subset expressing CD177. We demonstrate CD177+ TI-Tregs have ...

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Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated ...

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Jan 20, 2023 · Lung regeneration deteriorates with aging leading to increased susceptibility to pathologic conditions, including fibrosis. Here, we ...

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