Complete methylation was found in the promoter region of DLD1, HT29, RKO, and SW480 cells. Partial methylation was detected in LoVo, LS180, SW48, and SW620 ...
People also ask
What is the relevance of the promoter region being the target of methylation?
Although genetic changes are involved in the inactivation of genes with important anticancer functions (e.g., tumor suppressor and DNA repair genes), DNA methylation in a promoter region is an important epigenetic mechanism for the downregulation (silencing) of expression of these genes.
What is methylation of the promoter gene?
Gene promoter methylation is a common epigenetic event, taking place in the early phase of tumorigenesis, which has a great potential as a diagnostic and prognostic cancer biomarker.
What is the difference between hypermethylation and hypomethylation?
As compared with normal cells, the malignant cells show major disruptions in their DNA methylation patterns. Hypomethylation usually involves repeated DNA sequences, such as long interspersed nuclear elements, whereas hypermethylation involves CpG islands.
What is hypermethylation of the promoter region?
Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL).
