DLC1
![PDF] DLC1: a significant GAP in the cancer genome. | Semantic Scholar](/imgres?imgurl=https://d3i71xaburhd42.cloudfront.net/49b87c982be8b44b1c2c93eafda3bf0a5b2db8ce/5-Figure2-1.png&imgrefurl=https://www.semanticscholar.org/paper/DLC1%253A-a-significant-GAP-in-the-cancer-genome.-Lahoz-Hall/49b87c982be8b44b1c2c93eafda3bf0a5b2db8ce&h=456&w=1200&tbnid=adHZToRHaZVcTM&q=DLC1+gene&tbnh=57&tbnw=150&usg=AI4_-kT4ifLTMZh-LZSSweKyeAJMkmoOKQ&vet=1&docid=iwRaxrBV0buxLM&sa=X&ved=2ahUKEwjhtNKpk56GAxVP48kDHVwoCGYQ9QF6BAgIEAk)
Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 is a protein which in humans is encoded by the DLC1 gene.
This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a... Wikipedia
Molecular function: SH2 domain binding; protein binding; lipid binding; GTPase activator activity
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What does the DLC protein do?
DLC1 is a Rho GTPase-active protein (RhoGAP) that negatively regulates Rho proteins, which play critical roles in several cellular processes, including proliferation, polarity, motility, cytoskeletal remodeling, morphogenesis and vesicular trafficking [4].
Apr 3, 2024 · This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of ...
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small ...
Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans is encoded by the DLC1 gene.
DLC1 is localized at chromosome 8p21.3-22, a region that shows loss of hererozygosity (LOH) or heterozygous deletions in a large number and a wide variety of ...
Mar 25, 2020 · A Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to function as a tumor suppressor in various cancer ...
To identify genes involved in hepatocellular carcinoma (HCC; 114550), Yuan et al. (1998) applied representational difference analysis (RDA), ...
Full gene name according to HGNC. DLC1 Rho GTPase activating protein. Gene name i. Official gene symbol, which is typically a short form of the ...
Nov 2, 2021 · DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose ...
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling.
Deleted in liver cancer 1 (DLC1) is a recognized tumor suppressor gene that negatively regulates Rho family proteins by hydrolyzing the active GTP-bound state ...