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A comprehensive single-cell breast tumor atlas defines epithelial and immune heterogeneity and interactions ...
ScienceDirect.com
We present an integrated single-cell RNA sequencing atlas of the primary breast tumor microenvironment (TME) containing 236,363 cells from...
2 weeks ago
New trials show promise for immune checkpoint blockers in early-stage lung cancer
News-Medical
In a recent phase I trial published in the journal Cell Reports Medicine, researchers from Belgium administered a dendritic cell (DC)...
1 month ago
Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing
ScienceDirect.com
Drug repositioning seeks to leverage existing clinical knowledge to identify alternative clinical settings for approved drugs.
7 months ago
CRISPR-Cas9-mediated deletion of carbonic anhydrase 2 in the ciliary body to treat glaucoma
ScienceDirect.com
The carbonic anhydrase 2 (Car2) gene encodes the primary isoenzyme responsible for aqueous humor (AH) production and plays a major role in...
1 month ago
PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
ScienceDirect.com
Multiple cancers exhibit aberrant protein arginine methylation by both type I arginine methyltransferases, predominately protein arginine...
5 months ago
Beta-defensin index: A functional biomarker for oral cancer detection
ScienceDirect.com
There is an unmet clinical need for a non-invasive and cost-effective test for oral squamous cell carcinoma (OSCC) that informs clinicians...
2 months ago
Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
ScienceDirect.com
Targeting oncogenes at the genomic DNA level can open new avenues for precision medicine. Significant efforts are ongoing to target...
4 months ago
GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells
ScienceDirect.com
Lack of targetable antigens is a key limitation for developing successful T cell-based immunotherapies. Members of the unfolded protein...
6 months ago
Fc-fused IL-7 provides broad antiviral effects against respiratory virus infections through IL-17A-producing pulmonary ...
ScienceDirect.com
Repeated pandemics caused by the influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV) have resulted in serious...
4 months ago
NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking ...
ScienceDirect.com
Chronic myelomonocytic leukemia (CMML) is frequently associated with mutations in the rat sarcoma gene (RAS), leading to worse prognosis.
5 months ago